Practical Steps for Applying a New Dynamic Model to Near-Infrared Spectroscopy Measurements of Hemodynamic Oscillations and Transient Changes
نویسندگان
چکیده
a ht Rationale and Objectives: Perturbations in cerebral blood volume (CBV), blood flow (CBF), and metabolic rate of oxygen (CMRO2) lead to associated changes in tissue concentrations of oxyand deoxy-hemoglobin (DO andDD), which can bemeasured by near-infrared spectroscopy (NIRS). A novel hemodynamicmodel has been introduced to relate physiological perturbations andmeasuredquantities.Weseek to use this model to determine functional traces of cbv(t) and cbf(t) cmro2(t) from time-varying NIRS data, and cerebrovascular physiological parameters fromoscillatoryNIRSdata (lowercase letters denote the relative changes inCBV, CBF, andCMRO2with respect to baseline). Such a practical implementation of a quantitative hemodynamic model is an important step toward the clinical translation of NIRS.
منابع مشابه
A new hemodynamic model shows that temporal perturbations of cerebral blood flow and metabolic rate of oxygen cannot be measured individually using functional near-infrared spectroscopy.
A recent dynamic model relates the functional near-infrared spectroscopy (fNIRS) measurements to hemodynamic and metabolic parameters. This note reports modified expressions of the new model in terms of cerebral blood volume (CBV), blood flow (CBF) and metabolic rate of oxygen (CMRO2). On the basis of these modified expressions, the new model reproduces known steady state relationships between ...
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